![]() Injections directly into the joint are an option for OA pain. Acetaminophen can harm your liver, so never take more than prescribed and only use it as needed. The American College of Rheumatology (ACR) and Arthritis Foundation (AF) treatment guidelines released in 2020 don’t recommend it unless you can’t use NSAIDs. But recent studies suggest that acetaminophen does little for OA pain. You and your doctor should weigh the benefits and risks of NSAIDs.įor years, doctors recommended acetaminophen ( Tylenol, others) for OA. The risk increases the longer you use them and the more you take.Ĭelecoxib ( Celebrex) is an NSAID that’s less likely to cause gastrointestinal bleeding, but it can cause heart problems. NSAIDs also increase your chance of heart attack, stroke and heart failure. Without them, you can bruise easily, develop ulcers and may even bleed in your intestines. The problem is that some of those enzymes also help blood to clot and protect the lining of your stomach. All work by blocking enzymes that cause pain and swelling. They include ibuprofen ( Motrin, Advil) naproxen ( Aleve) and diclofenac ( Voltaren, others). NSAIDs are the most effective oral medicines for OA. ![]()
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